Abstract
The chapter discusses the structure and function of the human immunodeficiency virus of type 1 (HIV-1) reverse transcriptase (HIV-1 RT), a polymerase present in HIV-1, a causative agent of AIDS, and its inhibitors. HIV-1 RT is a multifunctional enzyme that contains DNA polymerase and RNase active sites, thus both the polymerase and RNase are good targets of antiviral drug development. The chapter describes the experimental as well as theoretical attempts made to exploit both for the development of potential anti-AIDS drugs. The chapter also presents a detail account of the structures of both.
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