Abstract
Mass spectrometry (MS) is a powerful platform for the discovery and routine determination of biochemical entities that mark the presence, type, and progression of disease. More so than most other analytical strategies, MS is particularly versatile and can be applied to the characterization and precise quantification of components in biological matrices including cell lines, formalin-fixed tissue, frozen tissue, blood, urine, and cerebral spinal fluid. Over the last few decades, there has been intensive research aimed at the discovery and development of new MS-based biochemical tests. In this chapter, we outline some of these efforts and discuss the challenges in the application of MS to the development of companion and complementary diagnostics.
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