Abstract
The diagnostic categories of autistic and psychotic disorders went through several revisions before being considered as separate entities in Diagnostic and Statistical Manual III in 1980. However, their conceptualization can sometimes still be difficult to conclude on because of some clinical and cognitive deficit overlaps as well as some common neurobiological characteristics. Patients presenting with autism spectrum disorders (ASDs) and psychotic experiences may pose particular diagnostic and management challenges. In addition, complex presentations characterized by functional decline, psychotic symptoms, and deterioration in social skills can be difficult to consistently categorize and treat. Further phenomenological, genetic, and neuroimaging research on the clinical boundaries and overlapping pathophysiology of ASD and psychosis may help better define their relationship and lead to more effective interventions.
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