Abstract

Pharmacological cognitive enhancement (CE) refers to the use of divergent psychoactive substances with the purpose of enhancing one's own cognition (e.g., increasing vigilance, concentration, memory). The group of substances for CE includes divergent over-the-counter drugs. Caffeine-containing products such as coffee, caffeinated drinks, and caffeine tablets are integral part of this group of substances. Furthermore, prescription drugs as well as illicit drugs belong to this group of CE substances (e.g., [psycho-]stimulants, modafinil). The use of caffeine in normal healthy subjects has very limited procognitive effects. However, there are few procognitive effects in healthy but sleep-deprived subjects. Caffeine shows provigilant effects with a lack of procognitive effects on higher cognitive domains (e.g., memory) in normal healthy subjects. Nevertheless, the use of coffee for CE is widespread among pupils and students, with a lifetime prevalence rate of 53% followed by the use of caffeinated drinks (lifetime prevalence, 39%) and caffeine tablets (lifetime prevalence, 11%).

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