Abstract
Studies show that drinking coffee is associated with both pleasure and a beneficial effect on health. Caffeine, which is the main coffee ingredient, may favorably affect a long list of diseases including malignant conditions. Caffeine may influence tumorigenesis by several ways, though the significant role of the immune system in tumor development is gaining solid support. Chronic, smoldering inflammation and tumor growth are closely related. With the initiation of the inflammatory process, immune cells are mobilized and start to produce inflammatory cytokines, which represent merely a single link of a lengthy chain of mechanisms related to conversion of normal cells to malignant ones. Stimulated tumor cells react by generation of inflammatory cytokines and growth factors and thus, an “immune dialog” between immune and cancer cells is activated. It is suggested that caffeine, by an alteration of the immune cross-talk between immune and cancer cells and promotion of anti-inflammatory activity may reduce the risk of cancer death.
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