Abstract
Zebrafish embryos represent a novel vertebrate platform for in vivo studies focusing on cancer biology. In this chapter, we will introduce the reader to the physiological processes that lead to the formation of the intersegmental vessels and the subintestinal vein plexus, two highly angiogenic areas widely employed for investigating the molecular mechanisms of tumor angiogenesis and for antiangiogenic drug discovery. Examples will be provided about the possibility to graft tumor cells and to follow new blood vessel development in zebrafish embryo in order to study the interplay between tumor and host microenvironment. In the last part of the chapter, the most common techniques used for vessel visualization in zebrafish embryo will be described and a brief compendium of the state-of-art imaging devices will be provided.
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