Abstract
This chapter discusses the industrial perspective of steroid bioconversions. 16α-Hydroxylation by Streptomyces roseochromogenes is used for the synthesis of triamcinolone. It is possible to make hydrocortisone from progesterone by hydroxylation at 11β, 17α, and 21; however, except for 11, the chemists can do it better. As 11α is forms, it drags down progesterone from solution as mixed crystals and that progesterone solution rate is proportion to the area of the particles, the area is the square of their concentration. The chapter discusses how the conversion of dienediol with S. affinis goes if the substrate is added simply as a single shot. To improve the substrate level, which is a prime factor in reducing labor and overhead costs, and the problem of incomplete conversion, which is a prime factor in yield and the costs associated with yield, it is necessary to address the interaction between diene and triene.
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