Abstract
Fragile X mental retardation protein (FMRP), the protein that is absent or dysfunctional in fragile X syndrome (FXS), is a multifunctional binding protein that associates with mRNAs and proteins in the brain. The loss of FMRP results in a number of molecular problems, including dysregulated protein synthesis of a subset of genes in the postsynapse, ion channel malfunction in the presynapse, and impaired response to DNA damage in the nucleus. Identification of FMRP-binding partners would help pinpoint the pathways and processes that are perturbed by the loss of the protein and provide therapeutic targets for the treatment of FXS. This chapter will discuss the latest approaches and discoveries regarding the RNA- and protein-binding targets of FMRP.
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