Abstract
Splicing is an important process in high eukaryotes. During the splicing process, the 5' end of the intron attacks the branch points to form a lariat RNA that is debranched by DBR1 to be linear and then degraded. Recent evidence shows that some lariat RNAs may escape the debranching process. Then after the free ends of lariat RNAs are degraded by enzymes, these lariat RNAs may form special circular RNAs. We discuss a computational pipeline for identifying lariat RNAs that escape the debranching process and become circular RNAs, and for quantifying their expression levels. Then we introduce another pipeline for identifying the branch points of introns. Finally, we show that some lariat RNAs function by inhibiting microRNA (miRNA) processing.
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