Abstract
Resveratrol is a dietary polyphenol that has attracted immense attention from biomedical researchers due to its numerous biological properties implicated for human health and disease. The molecular mechanisms that contribute to the beneficiary nature of resveratrol are multilayered and include epigenetic regulation. This chapter focuses on the effects of resveratrol, and its two natural analogs, on anticancer activity mediated by DNA methylation, histone modification, and microRNAs. Studies on resveratrol's epigenetic action, specifically histone deacetylase activity, add a new dimension to the expanding roles of resveratrol and its analogs as potential epichemopreventive and chemosensitizing agents. Clinical trials examining epigenetic changes facilitated by resveratrol and its analogs for cancer chemoprevention and therapy are urgently needed.
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