Chapter 7.9 - Abbott ARCHITECT® Family of Analyzers

Abstract

This chapter explains the technology and chemistry behind the ARCHITECT ® random-access family of analyzers for the quantitative determination of a broad range of analytes. The system consists of a family of immunoassay analyzers and modules, which may be combined with clinical chemistry tests (such as tests for glucose and sodium) by linking analyzers or using an integrated analyzer. Samples may be loaded at any time and urgent requests can be run in Stat mode. The immunoassays have a range of chemistries: immunoturbidimetric, particle-enhanced turbidimetric inhibition immunoassay (PETINIA), particle-enhanced turbidimetric immunoassay (PETIA), and enzyme multiplied immunoassay technique (EMIT), Assay designs may be homogeneous or heterogeneous, competitive or immunometric. The analysers can run one- and two-step assay protocols. The features of the different members of the analyzer family are listed, and the designs and principles explained. There are also sections on calibration, antibodies, separation, signal generation and detection, and data processing, including interfacing to laboratory information systems.