Abstract
Regulation of brain perfusion and oxygen/substrate delivery is, broadly speaking, dependent upon two partially overlapping systems. These are cardiovascular-respiratory regulation by the brainstem autonomic nervous system (ANS) centers and intrinsic cerebral autoregulatory systems (with minor contribution from the ANS). The period of transition from the relatively protected and supported intrauterine environment to the complexities of the external world requires the coordination of the newborn’s cardiovascular and respiratory systems.
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