Abstract
This chapter considers recent developments in the liquid chromatographic separation of enantiomers on a preparative scale. The chapter focuses on methods which allow the isolation of enantiomerically pure rather that slightly enriched materials. The recent development of chiral stationary phases (CSPs) effective for preparative work can be attributed largely to research done at the analytical level, for example, the separability of enantiomers on a given CSP can be evaluated quickly using a small quantity of racemate. Well-separated enantiomers are potential candidates for incorporation into “reciprocal” CSPs which should resolve compounds of the type used in the initial CSP. Any CSP which performs well at the analytical level can be used in preparative columns. Because the properties desired in a preparative chiral column are not unlike those required for any preparative separation, any treatment of preparative liquid chromatographic technique is relevant to the separation of enantiomers. The chapter discusses several chromatographic parameters specifically applied to CSPs.
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