Abstract
The liver is a unique organ that can regenerate to restore its mass while sustaining body homeostasis. Various cell signaling growth factors, cytokines, chemokines, their receptors, and cells are involved in the process of liver regeneration. To decipher the detailed mechanism of liver regeneration governing through signaling molecules and pathways, complete knowledge of their interconnected network is required. Although the cellular mechanism postinjury is well understood, liver regeneration in chronic liver diseases has not been achieved till now. Recent advances in regenerative therapy have encouraged the use of different stem cells to treat end-stage liver diseases. Nevertheless, a better understanding of signaling molecules, pathways, and cells in liver regeneration postacute or chronic liver injuries is imperative to optimize the liver regeneration capacity. This chapter deals with the plausible approach of liver regeneration using stem cells, signaling molecules, and pathways as potential targets to prevent liver diseases.
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