Abstract
Spontaneously occurring, natural, mutations have long been utilized in the analysis of the effects of genes on brain function and behavior. With the advent of recombinant DNA technologies, generation of artificially induced mutations has become a common practice in genetics, an approach that has been also often employed in the genetic analysis of brain function and behavior. The current chapter discusses advantages and disadvantages of using naturally occurring versus artificially induced mutations in neurobehavioral genetics. It reviews and compares these approaches, mainly focusing on conceptual issues. It serves as an introduction to subsequent chapters of this book that discuss specific methodological details.
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