Abstract
The association between oxidative stress and cardiovascular diseases caused by diseases of the coronary arteries has been well-established. Oxidative stress can cause lipid peroxidation, including oxidation of low-density lipoprotein (LDL). Oxidized LDL is directly linked to the development of plaques in coronary arteries, which eventually can cause myocardial infarction. In addition to oxidation of LDL, oxidative stress can cause cardiovascular diseases by other mechanisms. This chapter discusses the role of oxidative stress in the pathophysiology of atherosclerosis and related cardiovascular disease.
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