Abstract
A key challenge in cancer therapeutics is the administration of the optimum drug to the desired site of action. The poor solubility and bioavailability of many drugs causes constraints. Some of the challenges in drug delivery can be met by suitable surface-engineered nanocarriers. Various surface-modified drug delivery systems have been designed to release the drug in response to external stimuli that are specific to the tumor environment. This review is mainly focused on recent developments in the area of surface modification of inorganic and organic nanoparticles for selective delivery of anticancer drugs. In particular, the preparation, characterization, and surface modification of nanoparticles, and their application in cancer therapeutics are discussed. The roles of amphiphilic molecules in creating drug delivery systems through self-assembly approach are also discussed. Various examples of applications of liposomes, micelles, vesicles, hydrogels, protein, and polymer nanoparticles as well as the nanoparticles of metal, metal oxide, and their hybrid structure as efficient carriers of anticancer drug are briefly demonstrated.
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