Abstract
White adipocytes store excess energy in the form of triglycerides. During energy replete conditions, these triglycerides are broken down by lipolysis leading to the release of free fatty acids and glycerol. The free fatty acids are either released into the circulation where they are taken up by peripheral tissues or they are further processed in the adipocyte. The focus of this chapter will be on the signaling associated with the free fatty acid release, lipid species produced from these fatty acids in the adipocyte, and how these lipids are mobilized in the circulation. We will also discuss the contrast between acute stimulation of lipolysis in conditions such as fasting compared to the chronic stimulation of basal lipolysis observed in obesity.
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