Abstract
A plausible mechanism by which the human brain creates itself will be described. It is known that the developing brain makes many more synaptic/trophic connections than are required and then eliminates the incorrectly wired cells. Hypothesis 1: Each presumptive neuron expresses a unique set of receptors and trophic factors. Once each neuron produces its particular receptor groups, it becomes dependent on the trophic factors that bind to these receptors. Corollary 1: There is a quantization of trophic factor requirements, for example, if a cell expresses three quanta of a receptor it will require three quanta of the complementary trophic factor. Hypothesis 2: After a portion of the brain is wired the neurons are caused to fire constantly during rapid eye movement (REM) sleep. Only correctly wired neurons will receive their required trophic factors. Hypothesis 3: Improperly wired neurons will die by apoptosis. Hypothesis 4: Connectional developmental and age-related neurodegenerative diseases are produced, at least in part, by deficits in receptor–trophic factor interactions.
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