Abstract
While the effects of marijuana are fairly well understood, the recent rise in synthetic cannabinoid abuse has raised interest in the physiological and psychological effects of cannabinoids. Most of these “Spice” compounds act as full agonists at the cannabinoid 1 receptor (CB1R), and this has raised questions on whether these full agonists display differences in effect of (−)-trans-Δ9-tetrahydrocannabinol, a partial agonist. A selective review of the effects of both full and partial CB1R agonists is given, with highlights of what differences in effect they might possess. This includes case reports on the effects of Spice and marijuana on humans, as well as various methods of testing animals that compared partial and full CB1R agonists. Additionally, a description of problems in studying the effects of CB1R efficacy in vivo is given.
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