Abstract
Cotinine is the major metabolite of nicotine, which can be utilized as a proxy measure of recent tobacco use or passive exposure to cigarette smoke. This chapter provides an overview of cotinine urinalysis for detection of exposure to tobacco products. The metabolism of cotinine is briefly discussed, with reference to gender and ethnic differences in cotinine metabolism. Different assay methods are subsequently elucidated, including liquid and gas chromatographic techniques and immunoassay. The clinical, research, and public health applications of measurement of cotinine levels are discussed subsequently. The issues relating to sensitivity and specificity of cotinine urinalysis are highlighted. The chapter aims to provide a broad overview of the various aspects pertaining to cotinine urinalysis.
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