Abstract
Abstract This chapter focuses on the recent advances and applications of microdialysis in pharmacokinetic studies. The first section addresses the technical and theoretical issues regarding microdialysis experiments with an emphasis on obtaining pharmacokinetic data. The principles and methodologies for microdialysis probe calibration are examined. Various setups for microdialysis sampling and subsequent data analysis are also illustrated. The second section includes research articles since the year 2000, chosen from an extensive literature review to report and discuss the utilization and implications of microdialysis sampling in pharmacokinetics. These articles are discussed in three subsections dealing with the kinetics of drug delivery to specific targets, the kinetics of drug transport and metabolism, and the use of microdialysis to study the effects of pathophysiology or surgical intervention on pharmacokinetics. A concluding section briefly underscores the critical need to characterize microdialysis recovery in pharmacokinetic investigations.
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