Abstract
Black tea is a popular beverage worldwide that has attracted attention due to its myriad health benefits. The anti-cancer effects of black tea polyphenols have been amply demonstrated in a panel of human cancer cell lines, and in different organ sites in a wide range of animal tumor models. Human intervention trials, although inconclusive, have found an inverse association between black tea consumption and cancer risk in several case-control studies. Black tea polyphenols modulate the expression of a plethora of molecules that regulate proliferation, apoptosis, invasion, angiogenesis, and metastasis. Enzymes involved in chromatin remodeling are also affected, thereby restricting the clonal expansion of cancer cells. The pharmacological effects of black tea have been largely attributed to theaflavins. This chapter reviews the epidemiological, clinical, and experimental evidence for the chemopreventive potential of black tea polyphenols and the various molecular targets of black tea and its constituents on key signal transduction pathways.
Published Version
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