Abstract
Key goals in wound management are to achieve rapid wound closure and a functional and aesthetic scar. Extraordinary advances in cellular and molecular biology have greatly expanded the comprehension of the basic biological processes involved in wound repair and tissue regeneration. Wound repair is not a simple linear process in which growth factors released by phylogistic events activate parenchymal cell proliferation and migration, but is rather an integration of dynamic interactive processes involving soluble mediators, formed blood elements, extracellular matrix, and parenchymal cells. Unencumbered, these wound repair processes follow a specific time sequence and can be temporally categorized into three major groups: inflammation, tissue formation, and tissue remodeling. The three phases of wound repair, however, are not mutually exclusive but rather overlapping in time. Scientific breakthroughs in the processes of wound healing and tissue regeneration will lead to future therapeutic successes in wound care and tissue engineering.
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