Abstract
Alzheimer’s disease and related dementias (ADRDs) produce devastating health and economic burdens, and largely cannot be halted in their progression by any current therapeutics. This chapter will discuss how clustered regularly interspaced short palindromic repeats (CRISPR) and human-induced pluripotent stem cell (hiPSC) technologies may help reverse this dire situation. These tools are starting to provide better insight into ADRD pathogenesis via the generation of isogenic hiPSC disease models and CRISPR-based screens. CRISPR gene editing might also be used as a direct therapeutic to target critical disease-related genes as well as modify cellular therapeutics for enhanced efficacy. Although these approaches are largely described in the context of Alzheimer’s disease, it serves as a framework for how these technologies are being used for studying and potentially treating neurogenerative diseases more broadly.
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