Abstract
The extracorporeal clearance created by renal replacement therapy adds another route for drugs to be eliminated. Total drug clearance in patients receiving this therapy can be calculated as the sum of extracorporeal clearance plus the preexisting renal and nonrenal clearances. The A-V difference method and recovery method are described as two ways for calculating extracorporeal clearance in patients during hemodialysis. Drug clearance for patients receiving continuous renal replacement therapy is calculated on the basis of the dialysis saturation factor and ultrafiltration coefficient. Three methods are provided for estimating drug replacement doses for patients receiving renal replacement therapy. The use of these methods for treating drug intoxications is also discussed.
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