Abstract
Over the past 10years, new particle morphologies, particle chemistries, and phase chemistries have been developed that have enabled higher speed and resolution in liquid chromatography (LC). In particular, core–shell particles have shown superior performance compared to conventional fully porous particles. This chapter will discuss recent developments in stationary phase morphology and chemistry, with an emphasis on LC coupled to mass spectrometry (MS). The first part is dedicated to the theory of mass transfer properties in core–shell versus fully porous particles and will discuss speed/resolution properties of different phase morphologies using the kinetic plot model. The second part of the chapter will discuss new developments in particle and stationary phase chemistry that are particularly important with respect to LC/MS analysis.
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