Abstract
Targeted drug delivery (TDD) is emerging as a powerful tool for the treatment of cancer because of enhanced delivery of drugs, as well as genes, to a tumor site with protection from the extracellular environment. Stimuli-responsive nanogels (NGs) are three-dimensional hydrophilic polymer networks that are formed via covalent linkages or self-assembly processes and are able to change their structural properties in the presence of external stimuli. These NGs have been widely examined as smart drug delivery carriers for a variety of anticancer drugs, as well as genes, because of stability, ease of synthesis, good control over particle size, and easy functionalization. They can control sizes from 5 to 400nm, followed by different polymerization conditions. This chapter describes the recent progress on NG drug delivery systems (DDSs) for TDD and gene delivery in cancer cells. In this chapter, we briefly analyze the role of DDSs, importance of NGs in the TDD, stability in the extracellular and intracellular environment, cellular uptake behavior, internalization in the cells, degradation behavior in the cells, and transfection efficiency of NGs. This chapter also covers the advantages and drawbacks of responsive NGs and the future outlook for TDD and gene delivery in cancer cells.
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