Chapter 6 - Emerging role of inorganic and metal nanoparticles for the delivery of combination of drugs in wound healing and tissue regeneration

Abstract

The wound healing process is a complex sequence of orchestrated biochemical and cellular events that help in restoring skin and subcutaneous tissue. Treatment of wounds represents a major problem due to multifactorial pathophysiology. As already known, one of the major problems associated with wounds is the presence of microbial load at the wound site that ultimately leads to infection. Recently, researchers have established the fact that the design and development of nanoparticles (NPs) especially inorganic have promising antimicrobial effects in the case of wound healing. Inorganic NPs such as silver, gold, copper, zinc, titanium, and their derivatives have emerged as potential candidates for the treatment of wounds due to their various roles (antimicrobial, antiinflammatory, angiogenic activities) in wound healing. The nanoparticles exhibited a potent antibacterial effect when used in combination with biopolymers and drugs than alone. In this chapter, we focus on highlighting the role of inorganic and metal NPs for the delivery of a combination of drugs in wound healing and tissue regeneration along with their clinical status, challenges, and future directions