Abstract
This chapter provides an overview of chemical development. Chemical developments, of especially process chemistry, form a subdiscipline of organic chemistry. A compound worthy of chemical development offers commercial value as a medicine. Developmental work, therefore, involves only a drug candidate with desirable and selective pharmacological activities, which are specified as early as possible in the corresponding discovery effort. The chosen compound optimizes potency and selectivity in one or more animal models of a human disease. It shows high activity in a mechanism-based assay for antagonism, agonism, or enzyme inhibition and displays suitable pharmacokinetics. Chemical developers advance the chosen compound without seeking a pharmacologically superior substance deliberately or finding one serendipitously. Clinical physicians or discovery pharmacologists are more likely to make such a commercially valuable and serendipitous discovery than developmental chemists. Driven by sales potential, each development campaign, therefore, concentrates on a single outstanding compound. In addition, the chapter also discusses the purpose of chemical development.
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