Abstract
The concept of bioadhesive and phase change polymers initially appeared four decades ago and has since become one of the most investigated polymers for drug delivery systems. Some polymeric drug carriers attach to epithelial tissue or mucous membranes (bioadhesion). Epithelial tissues and mucous membranes often serve as possible adhesive sites for bioadhesive/mucoadhesive polymers, increasing the contact time between the drug and the site of action.Bioadhesive drug delivery systems address the drawbacks of conventional drug delivery systems by significantly reducing dosing frequencies and enabling prolonged controlled/sustained and targeted drug release with enhanced bioavailability. Studies have shown that by increasing the residence time at the application site, these carriers improve local therapeutic action and increase the systemic distribution of the drugs. These drug delivery strategies appear to help deal with drugs that are restrictive in oral or other traditional methods of administration, particularly acid-labile drugs or drugs that undergo first-pass metabolism.
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