Abstract
Despite recent progresses in the study of intestinal stem cells, organoid culture, and tissue-engineered intestine, there are many challenges that face the regeneration of small intestine probably due to its complex architecture and function. Developing novel methodology and technology to improve small intestinal repair and regeneration, particularly using large animals with gastrointestinal system that is similar to humans to verify murine model study results will enhance the clinical applications of these engineered intestines. In this chapter, we briefly outline the structure and cellular components of the small intestine and then describe the major stem cell types used in small intestine regeneration, including pluripotent stem cell–derived cells, adult intestinal stem cells, and mesenchymal stem cells. We also discuss recent progress in both the development of biological tissue-engineered grafts and tissue-engineered small intestines. Finally, we describe the role of stem cell–based transplantation in intestinal regeneration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
