Abstract
Quantitative high-resolution 3D imaging techniques have become important and widely used tools for evaluating bone quality in preclinical and clinical research studies of skeletal disorders related to vitamin D metabolism and bone mineral homeostasis. In this chapter we will review current state-of-the-art high-resolution computed tomography and magnetic resonance imaging, with a particular focus on technologies capable of imaging at the micro- and ultrastructural level of bone for clinical applications. A brief review of the physics and image acquisition process will be covered for each modality followed by a discussion of the quantitative image analysis techniques used to evaluate bone quality. Finally, a detailed overview of significant applications of these techniques will be presented.
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