Abstract
Integrated Approaches to Testing and Assessment (IATA) are a flexible tool for chemical safety assessment, based on the integration and translation of data derived from multiple methods and sources. In addition to traditional in vitro and in vivo tests, IATA are increasingly incorporating new approach methods, such as high-throughput screening and high-content imaging methods, along with computational approaches that are used as a means of data generation, interpretation and integration. In this chapter, we describe the historical development of IATA, from both conceptual and practical perspectives, and we assess the current status of IATA in toxicological decision-making.
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