Abstract
Cannabis allergy seems to be an increasing problem in the past few years. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations can vary from mild to life-threatening reactions, often depending on the route of exposure. Sensitization to cannabis can lead to secondary cross-allergies, such as plant-derived food allergies, which we have designated as the “cannabis-fruit/vegetable syndrome.” These secondary cross-allergies are mostly described in Europe, and result from cross-reactivity between nonspecific lipid transfer proteins (ns-LTPs) or thaumatin-like proteins (TLPs) present in Cannabis sativa and their homologs. At present, diagnosis of cannabis-related allergies rests upon history, skin testing, IgE-testing, and a basophil activation test. Treatment comprises strict avoidance measures, including an absolute stop of cannabis abuse.
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