Abstract
Despite advancements in dental tissue restoration therapies and those that replace missing teeth with artificial prostheses, clinical treatments are still not completely satisfactory because they do not regenerate tissues exhibiting the properties of natural teeth. Tissue engineering (TE) is a promising approach to regenerate dental tissues and whole teeth to restore tooth function. TE has the potential to create permanent biological replacements for soft and mineralized dental tissues such as periodontal ligament, dental pulp, dentin, cementum, alveolar bones, enamel, and even whole teeth. The major challenge in designing methods to create functional bioengineered dental tissues is the ability to mimic closely both the structural and anisotropic mechanical characteristics of the native dental tissues. The field of dental tissue regeneration (translational dentistry) has progressed toward the molecular and nanoscale design of biomimetic systems using stem cells, biomaterials, and bioactive agents. In this chapter, we will discuss dental tissue regeneration using principles of TE.
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