Abstract
Optical spectroscopy may be viewed as a variety of clever ways to beam light through samples to enable deductions about the materials with which the collected light interacted. This chapter gives an overview of three spectroscopic techniques commonly employed in the biopharmaceutical development laboratory: ultraviolet (UV) absorption spectroscopy, fluorescence spectroscopy, and Fourier Transform infrared spectroscopy (FT-IR). Each of these techniques is applied in a multitude of incarnations across the entire breadth of therapeutic protein discovery, development, and product quality control. The emerging field of biosimilars and the impact of robotic-based high-throughput screening instrumentation are two major factors that are currently driving a renewed embrace of these spectroscopic methods in support of a protein pharmaceutical development.
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