Abstract
There has been a tremendous shift in our understanding of adipose tissue from an inactive energy storehouse to an active endocrine organ. Adipose tissue is now known to secrete bio-active molecules called adipokines, which have been shown to exert critical effects on chondrocyte viability, with their dysregulation being implicated in obesity and osteoarthritis (OA). Here, we review the recent literature regarding their role in the pathophysiology of OA with emphasis on two key adipokines: Leptin and adiponectin, along with a new perspective on adipogenesis and its relationship to the progression and initiation of OA.
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