Abstract
In this chapter, we highlighted the research work on protein- and cellulose-based controlled release of drugs. Moreover, we presented the results of our published work dealing with the assessment of sodium caseinate compared to carboxymethyl cellulose, including the formulation of composite hydrogels with chitosan, as a safe drug delivery system for niacin (vitamin B3). This drug (NA) has been widely used as an anti-hyperlipidemic agent. To keep safer therapeutic concentrations of niacin drug for a specified time period, continuously a slow and sustained drug release behavior is necessary to avoid any toxic systemic effects. And when the loaded Sodium caseinate/chitosan loaded NA exhibited slow with sustained release and the maximum niacin drug was released in 24h, but the loaded carboxymethyl cellulose/Chitosan hydrogels showed initial burst release within 4h followed by a slower release up to 24h. Therefore, sodium caseinate is preferred over carboxymethyl cellulose to prepare hydrogels, offering an effective controlled niacin drug delivery system with reduced systemic side effects and improved intestinal targeting efficiency.
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