Chapter 5 - Nanoparticulate treatments for oral delivery

Abstract

This comprehensive review discusses various formulation perspectives that focus on the development of different types of nanoparticulate oral treatments such as solid lipid nanoparticles, polymeric nanoparticles, nanosuspensions, and nanomicelles. Various novel manufacturing methodologies for the fabrication of these different nanoparticulates are also discussed. The motivation for application of nanotechnology to the development of pharmaceutical (oral) dosage forms is manifold, including the need for improvement in bioavailability, specific targeting, physiological stability, or sustained action. Nanoparticles for pharmaceutical applications are truly on the rise. Commercial applications of multiple classes of nanoparticles for oral delivery have been commercialized for the treatment of various onerous ailments, including cancer, HIV, multiple sclerosis, and other central nervous system disorders. This review also briefly touches on novel nanopharmaceutical treatments currently under investigation. Application of nanotechniques for the development of oral pharmaceutical dosage forms has gained traction in the last decade because of a concerted effort on part of the industry and regulators alike. There is an abundance of detailed regulatory guidelines as well as innovation occurring for nanomanufacturing techniques, which will only serve the purpose of commercializing much needed novel medications.