Abstract
Multidrug resistance is a universal threat for human health as well as socioeconomic expansion. WHO has announced that antibacterial resistance is 1 of the 10 leading public health hazards. Multi- and Pan-resistance bacteria (superbugs) give rise to infections that are incurable with existing antibiotics. Mutations as well as plasmid-mediated resistance have led to upsurges of bacterial infections. Indiscriminate use of antibiotics has also developed antiviral and antifungal drug resistance. The scientists are now trying their best to prepare medicines from bacteriocins to overcome these problems. These are a group of antimicrobial toxic peptides synthesized in nature by ribosomes of Gram-positive bacteria called lantibiotics that are members of bacteriocins. These antimicrobial peptides are generally of two types. Type A inhibits the biosynthesis of bacterial cell wall or destroys the cell wall by punching holes on the bacterial cell surface in comparison; type B lantibiotics perform by interfering with the task of indispensable enzymes and increasing binding to target cell wall. In addition, variant lantibiotics with augmented qualities are being manufactured.
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