Abstract
It was in the 1800s that Claude Bernard declared that experimentation must involve the study of just one parameter, the independent variable, while all potential variables remain constant. Within all scientific experiments there are four types of variables; independent, dependent, controlled, and extraneous. While the independent, the condition that is changed in the experiment, and the dependent, the measurement of the results of the independent variable, are defined by the Principle Investigator, it is the responsibility of the animal care facility to identify and regulate the controlled and extraneous variables in experiments that involve the use of animals. The controlled variables are those parameters that must remain constant throughout all related experiments. The extraneous variables are those conditions or parameters that are not planned nor are they factored into results, and thus could result in errors in the scientific conclusions. This chapter will identify the controlled and extraneous variables that are common to experiments which involve the use of laboratory animals and the steps taken to prevent these variables from impacting experimental results.
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