Abstract
Fick's principle, “the speed of disappearing solute from the region is net flux,” has been applied to measure cardiac output and cerebral blood flow. The equation of Fick's first law of diffusion can be mathematically transformed into the equation of Fick's second law of diffusion. The concentration gradient of gases or small nonpolar lipid soluble molecules in the membrane was calculated using a model and solving the equation of Fick's second law of diffusion. It was evaluated to be linear when the concentrations of the both sides of membrane are maintained at different constant values. Pressure difference between the atmospheric pressure and alveoli per air flow through trachea gives the airway resistance. The pressure changes in the air-tight body plethysmograph with a patient sitting in give the alveolar pressure change in the lungs after correlation, which makes the measurement of the airway resistance possible without a cannulation into the patient.
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