Abstract
Chitosan is a natural biopolymer, which is extensively used in the formulation of colon-targeted drug-delivery systems. Chitosan-based systems lead to the release of drugs at the colon region by the subsequent degradation of chitosan. This degradation of chitosan occurs through the lysis of glycosidic bonds by the colonic microflora. Native chitosan and different chitosan derivatives, such as carboxymethyl chitosan, trimethyl chitosan, thiolated chitosan, N-succinyl chitosan, PEGylated chitosan, folic acid-conjugated chitosan, hyaluronic acid-coupled chitosan, etc., have widely been used in colon-targeted systems for the effective delivery of therapeutics.
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