Abstract
A major focus of neuroscience research has been to understand how intrinsic or sensory-driven synaptic activities sculpt neuronal networks during development. The brain-derived neurotrophic factor (BDNF) has emerged as a major target-derived messenger in the formation and plasticity of brain networks during development. Thus, a large amount of data now shows that BDNF can modulate the development and strength of glutamatergic and GABAergic synapses, as well as the extent and complexity of the dendritic arbor. This chapter summarizes recent advances that have established specific effects of postsynaptic BDNF secretion on the development and plasticity of brain networks during maturation.
Published Version
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