Abstract
Nutriphenomics is how diet influences an animal's phenotype. Many different diet choices are available to researchers studying rodent models, which can be broken into two basic categories: grain-based (GB) and purified diets. GB diets, which are made with cereal grains and animal by-products that contain multiple nutrients and non-nutrients, are typically closed formulas and contain compounds that can affect critical biomarkers in toxicological research. Purified diets are open formulas and have ingredients that contain one main nutrient, which allows one to report nutrient composition, reduce batch-to-batch variation, and revise the formula. This is an advantage when trying to induce a particular phenotype (from health to disease) while maintaining a consistent formula from one study to the next. These diet categories will be discussed in detail with respect to their contents and how they can affect an animal's phenotype, both intentionally and unintentionally.
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