Abstract
The lineage relationships and kinetics of the cellular components of bone are the focus of this chapter. Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature, stem or progenitor population. It is the latter model that applies to bone, and we will review here the definition of the skeletal stem cell (SSC), its relationship to descendent semicommitted osteoprogenitors and the terminally differentiated osteogenic cells that make up the mature bone. In addition, we will discuss the molecular and functional heterogeneity of SSCs in adult bones, their migration and kinetics in regulation of lifelong bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.
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