Abstract

Adaptive immunity is an essential part of the control of viral infections. There are two major arms of the adaptive immune system, consisting of B cells—the cells mainly producing antibodies—and T cells, which further separate into the CD4+ help T cells and the CD8+ cytotoxic T cells. While the main function of CD4+ T cells is the provision of help to antibody optimization by B cells and to activate CD8+ T-cells, CD8+ T cells provide a cytotoxic effect on infected cells. Since its first appearance in 2019, the SARS-CoV-2 virus and following COVID-19 disease have received extraordinary attention. An extensive body of work evaluates the function and kinetic of adaptive immunity on COVID-19. Here we review the role of T cells in COVID-19 and their role in disease severity.

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