Abstract
Pancreatic cancer (PC) is one of the most highly aggressive malignances in the United States. In recent years, accumulated evidence has demonstrated that the Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this chapter, we will summarize the roles of the Notch signaling pathway in cell proliferation, survival, apoptosis, migration, invasion, angiogenesis, metastasis, and drug resistance. Emerging evidence also has revealed that Notch regulates epithelial-to-mesenchymal transition (EMT) and cancer stem cells in PC. Thus, we will also discuss the novel functions of Notch in governing EMT and cancer stem cells in PC. Moreover, we will describe that the Notch signaling pathway could be downregulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients. In this chapter, we present the most up-to-date knowledge on the role of Notch in pancreatic cancer development, metastasis, and drug resistance, and also discuss the importance of systems levels analyses in understanding of Notch signaling.
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