Abstract
According to WHO, antimicrobial resistance (AMR) is one of the major public health concerns worldwide. Resistant microorganisms or “superbugs” gain AMR through multiple mutations, manifested as activation of efflux transporters, sequestration of antimicrobials, and restriction of drug internalization. Antimicrobial peptides (AMPs) are naturally known components of the innate immune system. AMPs are short stretches of amino acids having the ability to disrupt bacterial cell membranes. They are widely explored and wisely applied as therapeutic solutions to AMR. Recent advancement in AMP research, by chemical modifications, conjugations, and nanotization, has shown great potential in the design space to combat AMR. In this chapter the developments related to AMPs are discussed, along with various design strategies employed for bacterial targeting.
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